abstract：:Chondral or osteochondral lesions are typical injuries in orthopaedics and traumatology. Since there is no regeneration of damaged articular cartilage, these lesions can lead to premature osteoarthritis. Therefore, an adequate therapy for these injuries is an important goal. Nowadays, common methods in cartilage thera...

journal_title：Zeitschrift fur Rheumatologie

authors： Vogt S,Braun S,Imhoff AB

更新日期：2007-10-01 00:00:00

abstract：:Diagnosis and management of the rare disease systemic sclerosis (scleroderma) is a challenge for the physician, not least due to the possible multitude of organ systems involved. The medico-legal assessment is important for the patient claiming insurance benefits or applying for early retirement due to scleroderma. Bo...

journal_title：Zeitschrift fur Rheumatologie

authors： Graninger M

更新日期：2007-10-01 00:00:00

abstract：:Cytokine driven inflammation is a common feature in autoimmune diseases. Cytokines are needed under physiological conditions within the innate and adaptive immune systems to control infectious diseases and neoplastic disorders by regulation of the cell cycle and apoptosis. Cytokines can also be found in persistently i...

journal_title：Zeitschrift fur Rheumatologie

authors： Feuchtenberger M,Kneitz C,Tony HP

更新日期：2007-07-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease of still unknown etiology that results in characteristic destructive changes of the joints. Research of the past years has demonstrated that synovial fibroblasts play a central role in the initiation and perpetuation of these destructive changes. Stimulation of...

journal_title：Zeitschrift fur Rheumatologie

authors： Korb A,Peters M,Meinecke I,Pap T

更新日期：2007-07-01 00:00:00

abstract：:Clinical pathways for three rheumatological indications have been successfully developed in the rheumatological departments of two hospitals. These diseases were selected because of the number of inpatients seen and/or the costs for diagnostics and therapy. Three quota-concepts, the coordination of treatment processes...

journal_title：Zeitschrift fur Rheumatologie

authors： Lakomek HJ,Hülsemann JL,Küttner T,Buscham K,Roeder N

更新日期：2007-05-01 00:00:00

abstract：AIM:Our aim was to adapt and implement the evidence based recommendations for the management of ankylosing spodylitis (AS) of the "Assessments in AS" (ASAS) International Working Group together with the European League Against Rheumatism (EULAR) within the framework of a competence network (CN) in rheumatology in the G...

journal_title：Zeitschrift fur Rheumatologie

authors： Braun J,Zochling J,Märker-Hermann E,Stucki G,Böhm H,Rudwaleit M,Zeidler H,Sieper J

更新日期：2006-12-01 00:00:00

abstract：:In small vessel vasculitides, imaging studies aid in determining disease extent and activity, localization for biopsy, and for disease monitoring. They do not directly delineate the vasculitic lesion. Imaging studies focus on the upper and lower respiratory tract. Cranial magnetic resonance imaging (MRI) shows upper r...

journal_title：Zeitschrift fur Rheumatologie

authors： Schmidt WA,Both M,Reinhold-Keller E

更新日期：2006-11-01 00:00:00

abstract：:The enzyme poly-(ADP-ribose) polymerase (PARP) is localized within the cell nucleus and catalyzes DNA-repair. During programmed cell death (apoptosis), PARP is enzymatically cleaved. Detection of the cleavage products is characteristic for apoptosis. In patients with systemic lupus erythematosus (SLE), the highly orde...

journal_title：Zeitschrift fur Rheumatologie

authors： Böhm I

更新日期：2006-10-01 00:00:00

abstract：:Because it is a systemic disorder, rheumatoid arthritis (RA) is known to predispose affected individuals to other organ manifestations as well as arthritic problems. The serious complications include pericarditis, pulmonary and cutaneous nodules, episcleritis, and rheumatoid vasculitis. Of late, a significantly increa...

journal_title：Zeitschrift fur Rheumatologie

authors： Whelan P

更新日期：2006-10-01 00:00:00

abstract：:T-Large Granular Lymphocyte (T-LGL) leukaemia is a rare clonal disease characterized by neutropenia and/or anaemia. Because of its strong association with rheumatoid arthritis (RA), T-LGL leukaemia is an important differential diagnosis to Felty's syndrome. This differentiation might be especially difficult since, in ...

journal_title：Zeitschrift fur Rheumatologie

authors： Moosig F,Schoch R,Kneba M

更新日期：2006-09-01 00:00:00

abstract：:The improved options for effective treatment of osteoporosis and the shift to treatment strategies based on each patient's absolute fracture risk raise new questions in daily clinical care. Which patient should have what osteoprotective therapy and when and for how long? What techniques can be used to assess the indiv...

journal_title：Zeitschrift fur Rheumatologie

authors： Demary W

更新日期：2006-09-01 00:00:00

abstract：:Systemic sclerosis (SSc, scleroderma) is a multisystem disease with a bad prognosis. No drugs have been shown to cure this disease. In view of its pathogenesis, in which immune responses are presumed to play an important role, immune suppressive therapies are widely applied in the treatment of SSc. Recent placebo-cont...

journal_title：Zeitschrift fur Rheumatologie

authors： van den Hoogen FH

更新日期：2006-07-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a polymorphic and heterogenic systemic disorder with inflammation, fibrosis and vascular damage. Early diagnosis and classification may be difficult if disease expression is oligosymptomatic (undifferentiated), presenting with only Raynaud's phenomenon or limited scleroderma. Scleroderma sp...

journal_title：Zeitschrift fur Rheumatologie

authors： Genth E,Krieg T

更新日期：2006-07-01 00:00:00

abstract：:Autoimmune rheumatic diseases (ARD) affect young females during childbearing age. Over the last decades, improvements in survival as well as quality of life in patients affected with ARD have led to an increased number of pregnancies observed during the course of such diseases. Systemic lupus erythematosus (SLE) is th...

journal_title：Zeitschrift fur Rheumatologie

authors： Doria A,Iaccarino L,Ghirardello A,Arienti S,Zampieri S,Rampudda ME,Tincani A,Todesco S

更新日期：2006-05-01 00:00:00

abstract：:A 74-year-old female patient with rheumatoid arthritis was diagnosed with Pneumocystis jiroveci pneumonia (PcP) following therapy with methotrexate and prednisone. Although bactrim treatment was initiated and PcP was not detected by a control bronchoalveolar lavage, the patient died. The precise cause of death remains...

journal_title：Zeitschrift fur Rheumatologie

authors： Bertisch B,Ruef C

更新日期：2006-02-01 00:00:00

abstract：:Conventional radiography, ultrasonography (US), magnetic resonance imaging (MRI), computed tomography, and scintigraphy are imaging techniques in use for rheumatoid arthritis (RA). Conventional radiography of the hands and the forefeet should be performed every 6 to 12 months in the first two years, and every 12 to 24...

journal_title：Zeitschrift fur Rheumatologie

authors： Kellner H,Schmidt W,Rau R

更新日期：2005-11-01 00:00:00

abstract：:Osteoarthritis (OA) is the most common cause of functional disability in the elderly. Pain and loss of motion induce a vicious circle, leading to instability, frailty and ultimately invalidity. Currently, there is no treatment to reverse or slow the disease progression to a clinically meaningful extent. Thus, the prim...

journal_title：Zeitschrift fur Rheumatologie

authors： Brabant T,Stichtenoth D

更新日期：2005-10-01 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-beta superfamily. Their potential for organ and tissue regeneration and repair has been intensively investigated in recent years. Studies on fetal development have demonstrated the important role of these proteins for the development and diffe...

journal_title：Zeitschrift fur Rheumatologie

authors： Bramlage CP,Häupl T,Kaps C,Bramlage P,Müller GA,Strutz F

更新日期：2005-09-01 00:00:00

abstract：:The commission "Rehabilitation" of the German Society of Rheumatology compiled a data set for a routine report of the rehabilitation system for muskuloskeletal diseases. More than 250 rehabilitation hospitals offer inpatient rehabilitation for patients with musculoskeletal diseases. The prevalence of inpatient rehabil...

journal_title：Zeitschrift fur Rheumatologie

authors： Jäckel WH,Mau W,Zink A,Beyer W,Droste U,Engel M,Genth E

更新日期：2005-06-01 00:00:00

abstract：:Self-administered patient-centered questionnaires have been shown to be practical, reliable and valid in terms of evaluating functional limitations in rheumatic diseases. In systemic sclerosis a modified version of the HAQ and condition-specific questionnaires have been used. The Health Assessment Questionnaire (HAQ) ...

journal_title：Zeitschrift fur Rheumatologie

authors： Sigl T,Ewert T,Stucki G

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND:Quality of life as a part of the WHO definition of health is an important assessment tool for measuring the success in the treatment of chronic diseases. The short form 36 questionnaire (SF-36), which is measuring health related quality of life, was used in a multicentre placebo controlled study in patients ...

journal_title：Zeitschrift fur Rheumatologie

authors： Haibel H,Niewerth M,Brandt J,Rudwaleit M,Listing J,Sieper J,Braun J

更新日期：2004-10-01 00:00:00

abstract：:A 28-year-old female patient had load-dependent pain of the left knee. MRI showed an osteochondral defect of the medial condyle based on extensive osteonecrosis of the femoral and tibial bone. An association with a prior steroid treatment after cervical injury is most likely. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Steinhagen J,Rüther W

更新日期：2004-06-01 00:00:00

abstract：:Among the rheumatic diseases, systemic lupus erythematosus (SLE) reveals the highest frequency of central nervous symptoms. Psychiatric abnormalities are present in over 90% of the patients, if very mild cognitive impairment is included. The psychiatric syndromes listed by the American College of Rheumatologists encom...

journal_title：Zeitschrift fur Rheumatologie

authors： Haupt M

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Clinical observation suggests a frequent coincidence of back pain (BP) and fibromyalgia (FMA). Based on data from a population survey on back pain we studied the hypothesis of FMA being a frequent underlying condition of BP. We additionally studied the association of the severity of back pain and both chroni...

journal_title：Zeitschrift fur Rheumatologie

authors： Hüppe A,Brockow T,Raspe H

更新日期：2004-02-01 00:00:00

abstract：:Based on the most recent studies, it clearly appears that long-term hormone replacement therapy (HRT) prevents fractures but does not improve established coronary artery disease. In addition, HRT leads to a small increase in breast cancer incidence and to a decrease in colorectal cancer incidence. HRT increases the in...

journal_title：Zeitschrift fur Rheumatologie

authors： Uebelhart B,Frey D,Uebelhart D

更新日期：2003-12-01 00:00:00

abstract：:Impaired host immunity has been regarded as a predisposing factor in post-primary tuberculosis in adults. Patients with systemic lupus erythematosus (SLE) are usually exposed to high doses of corticosteroids and eventually develop defective cellular immunity that increases the risk for active tuberculosis. SLE-associa...

journal_title：Zeitschrift fur Rheumatologie

authors： Kocakoc E,Ozgocmen S,Kiris A,Ozcakar L,Boztosun Y,Yildirim N

更新日期：2003-12-01 00:00:00

abstract：:After approval of TNF and interleukin-1 inhibiting agents for treatment of refractory rheumathoid arthritis, new agents inhibiting interleukin-6 and costimulatory pathways are entering clinical phase I and II trials. Blockade of costimulation by using a CTLA4 immunoglobulin fusion protein (CTLA4Ig), which inhibits the...

journal_title：Zeitschrift fur Rheumatologie

authors： Perniok A,Rubbert-Roth A

更新日期：2003-10-01 00:00:00

abstract：:New strategies including the blockade of TNFalpha showed excellent therapeutic effects even in so far refractory rheumatic diseases. Moreover, these approaches provided us with important informations about the pathogenic role of the mediators involved and distinct autoimmune cellular subsets. Here, we discuss recent d...

journal_title：Zeitschrift fur Rheumatologie

authors： Feist E,Burmester GR,Dörner T

更新日期：2003-08-01 00:00:00

abstract：:Over the last ten years various biologics have been introduced in the therapy of rheumatic diseases. The most successful approach so far has been the inhibition of TNF alpha, which is able to suppress systemic inflammation in an unprecedented manner. However, the early observation of newly developed antinuclear antibo...

journal_title：Zeitschrift fur Rheumatologie

authors： Manger K,Manger B

更新日期：2003-06-01 00:00:00

abstract：:This article gives a comprehensive overview of diffuse interstitial lung diseases especially those associated with connective tissue diseases. Interstitial lung diseases (ILD) represent a heterogeneous group of diseases of very different and partially unknown etiologies. Therefore, an exact classification of the ILD i...

journal_title：Zeitschrift fur Rheumatologie

authors： Koller HK,Burghuber OC

更新日期：2003-04-01 00:00:00

abstract：:Patients with rheumatic diseases need a comprehensive and interdisciplinary treatment. In this context patient education takes the part to lead patients to a better self-management. The goals of patient education are the increase of knowledge and introspection, the positive influencing of attitudes and self-efficacy a...

journal_title：Zeitschrift fur Rheumatologie

authors： Ehlebracht-König I

更新日期：2003-01-01 00:00:00

abstract：:The German Rheuma-Liga as the largest patient organisation presents the different ways of informing patients. Patient- education-programs are presented, with a program focussing on social and psychological issues in particular. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Cattelaens K

更新日期：2003-01-01 00:00:00

abstract：:The diagnosis of rheumatoid arthritis has been hampered by the lack of a truly disease-specific serologic marker. Thus, despite its moderate specificity rheumatoid factor (RF) is still the only established marker antibody for RA and among the diagnostic criteria of the American College of Rheumatology the only serolog...

journal_title：Zeitschrift fur Rheumatologie

authors： Steiner G,Smolen JS

更新日期：2002-12-01 00:00:00

abstract：:We report on a 60 year old patient with peripheral neuropathy, neurogenic muscular atrophy, skin ulcers, arthritis and weakness. Detection of cryoglobulins in association with typical clinical symptoms, exclusion of hepatitis C and any other disease led to a rare diagnosis: essential cryoglobulinemic vasculitis. The c...

journal_title：Zeitschrift fur Rheumatologie

authors： Strunk J,Taborski U,Neeck G

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Psoriatic onycho-pachydermo-periostitis is a rare manifestation of psoriatic arthritis. It is characterized by the trias of psoriatic onychosis, tender soft tissue thickening, and osteoperiostitis of the distal phalanges in the absence of distal interphalangeal arthritis. Recommendations for the treatment of...

journal_title：Zeitschrift fur Rheumatologie

authors： Anders HJ,Sanden S,Krüger K

更新日期：2002-10-01 00:00:00

abstract：:The case of a 36-year old man with Behçet's disease (BS) for 16 years had low back pain and stiffness in the cervical and lumbar spine. He was diagnosed as having ankylosing spondylitis (AS). In this report we wish to emphasize the clinically occult co-existence of AS in BS and revelation of AS after a long time of BS...

journal_title：Zeitschrift fur Rheumatologie

authors： Cimen OB,Sahin G,Biçer A,Erdoğan C

更新日期：2002-08-01 00:00:00

abstract：:Evaluation of the sensitivity and value of magnetic resonance imaging (MRI) findings and miniarthroscopic investigations (mini-/needle-arthroscopy = MA) of metacarpophalangeal (MCP) joints in patients with rheumatoid arthritis (RA). 30 patients with RA (21 female, 9 male), disease duration 2 months to 22 years and mea...

journal_title：Zeitschrift fur Rheumatologie

authors： Peters R,Ostendorf B,Scherer A,Becker A,Dann P,Merk H,Mödder U,Schneider M

更新日期：2002-04-01 00:00:00

abstract：:Neuro-endocrine immune mechanisms play an important immunomodulatory role for rheumatic diseases as evidenced by long-recognized effects of glucocorticoids, gender, pregnancy, hemiparalysis, and stress on various clinical and epidemiological aspects. Recently, some regulatory pathways have been identified between the ...

journal_title：Zeitschrift fur Rheumatologie

authors： Straub RH,Schaible HG,Wahle M,Schedlowski M,Neeck G,Buttgereit F

更新日期：2002-04-01 00:00:00

abstract：:Within the group of inflammatory rheumatic diseases, spondyloarthropathy is the most common diagnosis after rheumatoid arthritis. Its prevalence was long underestimated. Ankylosing spondylitis (AS) and undifferentiated spondyloathropathy (uSpA) are the most common subgroups in western countries. There are still diffic...

journal_title：Zeitschrift fur Rheumatologie

authors： Haibel H,Rudwaleit M,Braun J,Sieper J

更新日期：2002-02-01 00:00:00

abstract：:Facing increasing health-related costs and limited health care resources, the assessment of cost effectiveness (CE) of medical procedures is also gaining considerable importance in the field of rheumatology. Since high annual therapy costs of 17,000-21,000 Euro are related to the employment of TNF-alpha blocking agent...

journal_title：Zeitschrift fur Rheumatologie

authors： Merkesdal S,Ruof J

更新日期：2002-01-01 00:00:00